Brain tumors in dogs similar to humans
The team aimed to identify whether glioma tumors developed in the same way in dogs and humans.
So, they assessed the molecular signatures of 83 posthumous glioma samples from dogs and compared them with human biopsies from adults and children.
The team employed a wide range of molecular sequencing technologies to obtain this information. They discovered that both humans and dogs shared mutations in genes that belong to well-known cell cycle pathways.
They found that several mutations appeared in both the human and the canine samples. This suggested for the first time that dogs and humans develop these types of tumors in a similar way.
The team also noticed that the gliomas in dogs were more like gliomas in children than they were to adults, and discovered that the mutations occurred at similar times of life in both canines and children.
For example, adult tumor samples harbored mutations in the gene IDH1, but these occurred at only a low rate in pediatric and canine samples.
They also saw other similarities between tumor samples from dogs and children. These included changes in the number of chromosomes.
Finally, the team found that changes in the immune system in the tissue surrounding the tumors were similar between human and canine samples.
Treating dogs to help people
The researchers believe that using existing treatments to cure glioma in dogs could lead to advances in treating the condition in humans.
Using immunotherapy on dogs would allow researchers the opportunity to find ways to make it more successful in humans.
These results could help scientists understand the relationship between other human cancers and those of dogs. This, in turn, could lead to the development of better treatments for both species.
If the information from this new study leads to developments in cancer research and treatments, dogs really could be a person’s best friend.
Originally Published at: https://www.medicalnewstoday.com/articles/dogs-could-be-the-missing-link-for-understanding-brain-cancer